PRODUCT DETAIL

Composition

• Active ingredients:
• Brimonidine tartrate 0.2%
• Timolol maleate 0.5%
• Ophthalmic (eye drop) solution

Indication / Use

Used for:

• Reduction of elevated intraocular pressure (IOP)
• Treatment of:
• Open-angle glaucoma
• Ocular hypertension

Usually prescribed when a single medication is not sufficient.

Direction of Use

• Instill 1 drop into affected eye(s)
• Usually twice daily about 12 hours apart
• If using other eye medications, allow at least 5 minutes between drops
• Remove contact lenses before use and reinsert after about 15 minutes

Side Effects

Common side effects:

• Eye redness
• Burning or stinging sensation
• Dry eyes
• Blurred vision
• Drowsiness
• Headache
• Dry mouth

Possible serious side effects:

• Slow heartbeat (bradycardia)
• Difficulty breathing
• Chest pain
• Severe allergic reaction
• Low blood pressure
• Fainting

Warnings

• Contraindicated in patients with:
• Asthma
• Severe chronic obstructive pulmonary disease (COPD)
• Sinus bradycardia
• Heart block
• Heart failure
• Avoid use in patients allergic to brimonidine or timolol
• May mask symptoms of low blood sugar in diabetics
• May worsen muscle weakness in myasthenia gravis

Interactions

May interact with:

• Beta-blockers
• Antihypertensive medications
• Digoxin
• Calcium channel blockers
• CNS depressants
• MAO inhibitors
• Antidepressants
• Insulin and oral antidiabetic drugs

Caution

• Use cautiously in:
• Elderly patients
• Diabetics
• Patients with cardiovascular disease
• Patients with respiratory disorders
• Avoid driving if vision becomes blurred or dizziness occurs
• Do not touch dropper tip to avoid contamination
• Inform doctor if pregnant or breastfeeding

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