PRODUCT DETAILS

Composition

• Aciclovir (Acyclovir) 5% w/w cream
  (50 mg aciclovir per gram of cream)

Category / Class

• Topical antiviral medication
• Anti-herpes simplex virus (HSV) cream

Use / Indications

Used for:

• Recurrent cold sores (herpes labialis)
• Herpes simplex virus infections affecting lips and face

Mechanism of Action

Aciclovir inhibits viral DNA replication by blocking herpes virus DNA polymerase, thereby slowing multiplication of HSV-1 and HSV-2 viruses.

Direction of Use

Typical dosage:

• Apply 5 times daily at approximately 4-hour intervals
• Usually used for 4–5 days (up to 10 days if needed)

Instructions:

• Start treatment as early as possible (tingling/prodrome stage)
• Apply thin layer to affected area
• Wash hands before and after application
• Avoid rubbing cold sore unnecessarily
• Avoid touching eyes after applying cream
• For external use only

Common Side Effects

• Burning or stinging sensation
• Dry or cracked lips
• Skin peeling/flaking
• Mild itching
• Redness
• Skin dryness

Serious Side Effects

Seek medical attention if patient develops:

• Severe allergic reaction
• Swelling of lips/face/tongue
• Difficulty breathing
• Severe rash or eczema
• Angioedema/anaphylaxis (rare)

Warnings

Do NOT use in:

• Allergy to aciclovir or valaciclovir
• Eyes, inside mouth, nose, or genital area
• Immunocompromised patients unless prescribed

Important warnings:

• Does not cure herpes permanently
• Does not completely prevent transmission
• Avoid kissing or close contact during active outbreak
• Avoid sharing towels, lip products, utensils during outbreak

Drug Interactions

• Significant systemic interactions are unlikely because topical absorption is minimal
• Use cautiously with:
• Other topical irritant products
• Other antiviral creams unless prescribed

Cautions

• Best effectiveness occurs when started early
• Avoid excessive rubbing of lesions
• Wash hands frequently to reduce spread
• Temporary irritation may occur after application
• Use cautiously in pregnancy and breastfeeding under medical advice