Composition:

• Loratadine 5 mg per 5 mL (1 mg/mL)
• Excipients may include: glycerol, propylene glycol, sucralose/sorbitol/maltitol, sodium benzoate, citric/phosphoric acid, flavoring agents, and purified water (varies slightly by manufacturer)

Use / Indication:
Used for the relief of symptoms of allergic conditions, including:

• Allergic rhinitis (hay fever: sneezing, runny or itchy nose, nasal congestion)
• Allergic conjunctivitis (itchy/watery eyes)
• Chronic urticaria (hives and skin itching)

Direction of Use:

• Adults and children ≥12 years: 10 mL (10 mg) once daily
• Children 2–12 years:

o    30 kg: 10 mL once daily

• ≤30 kg: 5 mL once daily
• Not recommended for children under 2 years
• Can be taken with or without food

Side Effects:

• Headache (common in children)
• Fatigue or tiredness
• Nervousness
• Drowsiness (uncommon but possible)
• Increased appetite
• Insomnia
• Rare: rash, dry mouth, dizziness, palpitations, allergic reactions

Warnings:

• Do not exceed recommended dose
• Discontinue and seek medical help if severe allergic reaction occurs
• Stop at least 48 hours before allergy skin testing
• Use caution in severe liver impairment (dose adjustment may be needed)
• Very rare cases of serious liver or hypersensitivity reactions have been reported

Drug Interactions:

• CYP3A4 or CYP2D6 inhibitors may increase loratadine levels
• Alcohol does not significantly increase sedative effects, but caution is still advised
• May interact with strong antifungals or certain antibiotics affecting liver enzymes

Caution:

• Use in pregnancy only if clearly necessary (risk vs benefit)
• Avoid breastfeeding use unless advised by a clinician (passes into breast milk)
• Use carefully in liver disease
• Although considered “non-drowsy,” some patients may still experience sedation or fatigue
• Avoid driving or operating machinery if affected