PRODUCT DETAILS

Composition

• Active ingredient: Diphenhydramine hydrochloride 2% w/w
• Class: Topical antihistamine (H1 blocker)
• Other ingredients (may vary by brand):
• Cream base (emollients/ointments)
• Preservatives such as parabens or benzoates (varies by manufacturer)
  
  

Indication / Use

Used for short-term relief of minor allergic skin reactions, such as:

• Insect bites and stings
• Itchy rashes (pruritus)
• Urticaria (nettle rash/hives)
• Mild sunburn irritation
• Localized allergic skin reactions
  
  

It is meant for small, limited areas of skin only.

Direction of Use

• Apply a thin layer to affected area
• Usually up to 2 times daily
• Use for short periods only (max ~3 days)
• Wash hands after application
• Avoid large or repeated applications
  
  

Side Effects

Common:

• Mild stinging or burning
• Skin redness or irritation
• Dryness or peeling

Possible allergic effects:

• Worsening rash (contact sensitisation)
• Photosensitivity (skin becomes more sensitive to sunlight)
• Rare eczema-like reaction

Systemic effects (rare, if overused or on large areas):

• Drowsiness or sedation
• Dizziness
• Dry mouth
• Confusion (especially in children/elderly)
  
  

Warnings

• Do NOT use:
• On broken, raw, or infected skin
• On large areas of body
• For more than a few days
• In children under 6 years
• Avoid contact with:
• Eyes
• Mouth
• Mucous membranes
  
  

Interactions

• No major drug interactions when used correctly
• Risk increases if combined with:
• Other diphenhydramine products
• Strong sedatives (if absorbed systemically in excess)

Caution

• Can cause sensitization (allergy to the cream itself) with repeated use
• Overuse can make itching worse instead of better
• Stop if rash spreads or worsens
• Sun exposure may worsen skin reaction (photosensitivity risk)
• If symptoms persist, a different treatment (e.g., steroid cream or oral antihistamine) may be needed