PRODUCT DETAILS

Composition

Contains:

• Latanoprost 0.005%
• Timolol maleate 0.5% (drugs.com)

Category / Class

• Combination anti-glaucoma eye drop
• Prostaglandin analogue + beta-blocker ophthalmic preparation

Use / Indications

Used for:

• Open-angle glaucoma
• Ocular hypertension
• Patients insufficiently controlled with single glaucoma medication (drugs.com)

Mechanism of Action

• Latanoprost increases aqueous humour outflow from the eye.
• Timolol decreases aqueous humour production.

Together they reduce intraocular pressure more effectively than either medicine alone.

Direction of Use

Typical dosage:

• 1 drop into affected eye(s) once daily

Instructions:

• Preferably use in the evening
• Wash hands before use
• Avoid touching dropper tip
• Remove contact lenses before instillation
• Reinsert contact lenses after at least 15 minutes
• If using other eye drops, wait at least 5 minutes between medications  

Common Side Effects

Eye-related:

• Eye redness
• Burning/stinging
• Blurred vision
• Eye irritation
• Dry eyes
• Increased eyelash growth
• Darkening of iris or eyelids

Systemic (timolol-related):

• Slow heart rate
• Fatigue
• Dizziness
• Shortness of breath

Serious Side Effects

Seek urgent medical attention if patient develops:

• Wheezing or breathing difficulty
• Chest pain
• Severe dizziness/fainting
• Severe allergic reaction
• Significant vision changes
• Severe eye pain/swelling
• Heart rhythm disturbances  

Warnings

Do NOT use in:

• Asthma or severe COPD
• Sinus bradycardia
• Heart block
• Heart failure
• Allergy to latanoprost or timolol
• Severe respiratory disease

Important warnings:

• Timolol may be systemically absorbed and act like oral beta-blockers
• Iris colour change may be permanent
• May mask signs of hypoglycaemia in diabetics
• Use cautiously in thyroid disease

Drug Interactions

Use cautiously with:

• Oral beta-blockers
• Calcium channel blockers
• Digoxin
• Antiarrhythmics
• Other glaucoma drops
• Insulin/antidiabetic medicines
• CYP2D6 inhibitors (e.g., fluoxetine, quinidine)

Cautions

• Perform punctal occlusion (close eyes gently after instillation) to reduce systemic absorption
• Temporary blurred vision may impair driving
• Monitor pulse and breathing in susceptible patients
• Use cautiously in:
• Diabetes
• Heart disease
• Respiratory disease
• Peripheral vascular disease
• Store according to manufacturer instructions