PRODUCT DETAILS

Composition

• Brinzolamide 10 mg/ml
• Timolol 5 mg/ml

Category / Class

• Carbonic anhydrase inhibitor + Beta-blocker combination eye drop

Use / Indications

Used for:

• Open-angle glaucoma
• Ocular hypertension (high pressure inside the eye)

How It Works

AZARGA reduces the production of fluid (aqueous humour) inside the eye, thereby lowering intraocular pressure.

Direction of Use

• Usually: 1 drop in affected eye(s) twice daily (morning and evening)
• Shake bottle well before use
• Wash hands before application
• Avoid touching dropper tip to the eye
• If using other eye drops, wait at least 5 minutes between medications
• Remove soft contact lenses before use and reinsert after 15 minutes
• Press the inner corner of the eye for 1–2 minutes after instillation to reduce systemic absorption

Common Side Effects

Eye-related:

• Blurred vision
• Burning or stinging sensation
• Eye irritation/redness
• Dry eyes
• Eye pain
• Bitter or unusual taste in mouth

Less common:

• Fatigue
• Slow heartbeat
• Cough
• Headache
• Nausea

Warnings

Do not use if patient has:

• Asthma or severe COPD
• Severe heart problems
• Severe kidney disease
• Sulphonamide allergy
• Allergy to beta-blockers
• Hyperchloremic acidosis

Drug Interactions

Use cautiously with:

• Oral beta-blockers
• Calcium channel blockers
• Anti-arrhythmics (e.g. amiodarone)
• Digoxin
• Antidiabetic drugs
• MAO inhibitors

Cautions

• May temporarily blur vision; avoid driving immediately after use
• Use cautiously in diabetes because timolol may mask hypoglycaemia symptoms
• Caution in liver disease, dry eye disease, and corneal disorders
• Not recommended in pregnancy or breastfeeding unless prescribed
• Avoid contamination of the bottle tip
• Discard bottle 4 weeks after opening