PRODUCT DETAILS

Composition

• Brinzolamide 1% (10 mg/mL)
• Brimonidine tartrate 0.2% (2 mg/mL)

Category / Class

• Combination anti-glaucoma eye drop
• Carbonic anhydrase inhibitor + Alpha-2 adrenergic agonist ophthalmic preparation

Use / Indications

Used for:

• Open-angle glaucoma
• Ocular hypertension (raised intraocular pressure)
• Patients inadequately controlled with a single glaucoma medication

Mechanism of Action

• Brinzolamide reduces aqueous humour production by inhibiting carbonic anhydrase.
• Brimonidine decreases aqueous humour production and increases fluid drainage from the eye.

Together, they lower intraocular pressure and help protect the optic nerve.

Direction of Use

Typical dosage:

• 1 drop into affected eye(s) 2–3 times daily depending on prescription

Instructions:

• Shake bottle well before use
• Wash hands before application
• Avoid touching dropper tip
• Wait at least 5 minutes between different eye drops
• Remove contact lenses before use and reinsert after about 15 minutes
• Press inner corner of eye for 1 minute after instillation to reduce systemic absorption

Common Side Effects

Eye-related:

• Blurred vision
• Eye redness
• Eye irritation or itching
• Dry eyes
• Eye allergy
• White residue or “gunk” in eye corners

Systemic:

• Bitter or unusual taste
• Dry mouth
• Drowsiness/fatigue
• Dizziness

Serious Side Effects

Seek medical attention if patient develops:

• Severe eye pain
• Vision changes 
• Severe allergic reaction
• Swollen eyelids
• Breathing difficulty
• Severe skin reactions
• Excessive sleepiness or fainting

Warnings

Do NOT use in:

• Sulfonamide allergy
• Severe kidney disease
• Hyperchloremic acidosis
• Children under 2 years
• Patients taking MAO inhibitors or certain antidepressants
• Hypersensitivity to brinzolamide or brimonidine

Drug Interactions

Use cautiously with:

• Oral carbonic anhydrase inhibitors (acetazolamide)
• CNS depressants/alcohol
• Antihypertensives
• Cardiac glycosides (digoxin)
• MAO inhibitors
• Tricyclic antidepressants
• High-dose salicylates

Cautions

• May cause drowsiness; avoid driving immediately after use
• Temporary blurred vision is common
• Use cautiously in:
• Depression
• Low blood pressure
• Heart disease
• Raynaud’s syndrome
• Liver disease
• Diabetes
• Contains preservative that may irritate eyes and discolor soft contact lenses
• Long-term use may worsen dry eye symptoms