PRODUCT DETAILS

Composition

Each mL contains:

• Tobramycin 0.3% (3 mg/mL)
• Dexamethasone 0.1% (1 mg/mL)

Category / Class

• Ophthalmic antibiotic + corticosteroid combination
• Aminoglycoside antibiotic + steroid eye preparation

Use / Indications

Used for:

• Bacterial eye infections with inflammation
• Bacterial conjunctivitis
• Blepharitis
• Keratitis (non-viral)
• Post-operative eye inflammation
• Prevention and treatment of inflammation after eye surgery (e.g., cataract surgery)

Mechanism of Action

• Tobramycin kills susceptible bacteria causing eye infection.
• Dexamethasone reduces inflammation, redness, swelling, and irritation.

Direction of Use

Typical dosage:

• 1–2 drops into affected eye(s) every 4–6 hours
• Severe cases:
• May be used every 2 hours during the first 24–48 hours, then gradually reduced

Instructions:

• Shake well before use
• Wash hands before application
• Avoid touching dropper tip
• Wait about 5 minutes between different eye medications
• Press inner corner of the eye for 1 minute after instillation to reduce systemic absorption
• Remove contact lenses before use and reinsert after at least 15 minutes

Common Side Effects

• Burning or stinging
• Eye irritation
• Redness
• Itching
• Blurred vision
• Eyelid swelling
• Watery eyes
• Sensitivity to light
• Bitter taste occasionally

Serious Side Effects

Especially with prolonged use:

• Increased intraocular pressure (glaucoma)
• Cataract formation
• Optic nerve damage
• Delayed wound healing
• Secondary fungal, bacterial, or viral infections
• Severe allergic reactions
• Vision changes or halos around lights

Warnings

Do NOT use in:

• Viral eye infections (e.g., herpes simplex, varicella)
• Fungal eye infections
• Untreated mycobacterial eye infections
• Allergy to tobramycin, dexamethasone, or aminoglycosides

Important warnings:

• Long-term steroid use can increase eye pressure
• Steroids may mask worsening infections
• Eye pressure monitoring is recommended if used longer than 10 days

Drug Interactions

Use cautiously with:

• Other steroid eye medications
• Oral/systemic steroids (e.g., prednisone)
• Other aminoglycoside antibiotics
• Immunosuppressive medications
• CYP3A4 inhibitors may increase steroid effects in susceptible patients

Cautions

• Temporary blurred vision may impair driving
• Avoid prolonged unsupervised use
• Avoid wearing contact lenses during active infection
• Use cautiously in glaucoma patients
• Use cautiously in diabetes due to increased infection risk
• Discard bottle according to manufacturer guidance after opening