PRODUCT DETAILS

Composition

Commonly contains a combination of:

• Paracetamol (Acetaminophen)
• Chlorpheniramine maleate
• Phenylephrine
  (Formulations may vary slightly by manufacturer/country.)

Category / Class

• Night-time cold and flu medication
• Analgesic + antihistamine + decongestant

Use / Indications

Used for relief of:

• Night-time cold and flu symptoms
• Fever
• Headache
• Body aches
• Runny nose
• Sneezing
• Nasal congestion
• Difficulty sleeping due to cold symptoms

Mechanism of Action

• Paracetamol reduces fever and pain.
• Chlorpheniramine reduces sneezing, runny nose, and allergy symptoms while causing sedation.
• Phenylephrine relieves nasal congestion by shrinking swollen blood vessels in the nose.

Direction of Use

Typical adult dosage:

• Usually 1–2 capsules/tablets at night or every 4–6 hours as directed

Instructions:

• Take with water
• Preferably use at bedtime because it may cause drowsiness
• Do not exceed recommended daily dose
• Avoid combining with other paracetamol-containing medicines

Common Side Effects

• Drowsiness
• Dry mouth
• Dizziness
• Blurred vision
• Constipation
• Nausea
• Mild nervousness
• Difficulty concentrating

Serious Side Effects

Seek urgent medical attention if patient develops:

• Severe allergic reaction
• Difficulty breathing
• Severe dizziness/fainting
• Fast or irregular heartbeat
• Severe liver problems
• Confusion or agitation

Warnings

Do NOT use in:

• Severe liver disease
• Severe hypertension
• Severe heart disease
• Narrow-angle glaucoma
• Allergy to ingredients

Important warnings:

• May cause significant drowsiness
• Avoid alcohol
• Do not drive or operate machinery after use
• Excess paracetamol may cause liver damage

Drug Interactions

Use cautiously with:

• Alcohol
• Sedatives/sleeping tablets
• Antidepressants
• MAO inhibitors
• Other antihistamines
• Other cold and flu medications
• Warfarin

Cautions

• Use cautiously in:
• Elderly patients
• Asthma patients
• Enlarged prostate
• Glaucoma
• Maintain adequate hydration
• Avoid daytime use if excessive drowsiness occurs
• Seek medical advice if symptoms persist beyond several days