PRODUCT DETAILS

Composition

• Silver sulfadiazine 1% w/w
  (10 mg silver sulfadiazine per gram of cream) 

Category / Class

• Topical antimicrobial / antibacterial cream
• Sulfonamide derivative burn medication

Use / Indications

Used for:

• Prevention and treatment of burn wound infections
• Second-degree burns
• Third-degree burns
• Infected skin ulcers or wounds (in some cases)
• Skin graft donor sites

Mechanism of Action

• Silver ions damage bacterial cell membranes and enzymes.
• Sulfadiazine inhibits bacterial folic acid synthesis.

Together, they provide broad-spectrum antimicrobial activity against many bacteria and some fungi.

Direction of Use

Typical application:

• Apply a thin layer (about 1–2 mm thick) to cleaned burn/wound area
• Usually once or twice daily

Instructions:

• Clean and debride wound before application
• Use sterile gloves or applicator if possible
• Cover entire affected area continuously
• Dressing may or may not be used depending on clinician advice
• Reapply after bathing or wound cleansing  

Common Side Effects

• Burning sensation
• Itching
• Rash
• Skin discoloration
• Pain at application site
• Temporary leukopenia (low white blood cells) in some patients

Serious Side Effects

Seek urgent medical attention if patient develops:

• Severe allergic reaction
• Extensive rash or skin peeling
• Fever/sore throat (blood disorders)
• Liver problems
• Kidney problems
• Stevens-Johnson syndrome/toxic epidermal necrolysis (rare)
• Severe skin discoloration

Warnings

Do NOT use in:

• Sulfonamide allergy
• Premature infants
• Infants under 2 months
• Near-term pregnancy
• Severe G6PD deficiency without supervision

Important warnings:

• May delay wound healing in some burns
• Long-term extensive use may cause systemic absorption
• Monitor blood counts in large burn areas
• Avoid contact with eyes

Drug Interactions

Use cautiously with:

• Other topical antimicrobials
• Enzymatic debriding agents (may become inactive)
• Sulfonamide-containing medications
• Drugs affecting bone marrow

Cautions

• Use cautiously in:
• Kidney disease
• Liver disease
• G6PD deficiency
• Avoid unnecessary prolonged use
• Large surface area treatment may increase systemic effects
• Keep treated area clean to prevent secondary infection